产品名称:重组小鼠tumour抑制素M(OSM)

产品英文名称:Mouse Oncostatin M Protein

货号:PRP1307

产品特点&优势:
通过LAL法测定,每微克蛋白里内毒素含量<1.0 EU。

重组小鼠tumour抑制素M(OSM)产品背景:
Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Oncostatin M (OSM) is considered as a pleiotropic cytokine that signals through cell surface receptors typeⅠand typeⅡ both of which share the similarity of containing protein gp130 and takes part in many bio metabolism processes including liver development, hematopoiesis, inflammation, bone formation, and destruction and possibly CNS development. Oncostatin M (OSM) was previously identified by its ability to inhibit the growth of cells from melanoma and other solid tumors. It also has been reported that OSM, like LIF, IL-6, and G-CSF, can inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells. The human form of OSM is insensitive between pH2 and 11 and resistant to heating for one hour at 56 degrees but is not stable at 90 degrees. The human OSM is produced as a precursor containing 252 amino acids, whose first 25 amino acids function as a secretory signal peptide and which on removal yields the soluble 227 amino acid pro-OSM. Removal of the C-terminal most 31 amino acids produces the fully active 196 residue form.

序列:
氨基酸序列来源于:重组小鼠tumour抑制素M(OSM) (P53347) (Ala24-Arg206) 表达的蛋白片段。

标签:无标签

活性:
Testing in Progress

蛋白长度:
重组小鼠tumour抑制素M(OSM)由183个氨基酸组成,预测分子量为20.39 KD。

分子:
OSM; OS-M; Oncostatin M

检测指标:
OSM; OS-M; Oncostatin M

产品形式:冻干粉,冻干缓冲液为无菌的20 mM Tris,150 mM NaCl,pH 7.4。

重组小鼠tumour抑制素M(OSM)产品注意事项:
开盖使用前,请先离心。本产品为冻干粉,推荐用该产品配套的Reconstitution Buffer进行复溶,且浓度不低于100 μg/mL。客户可根据后续的实验需求,进行进一步的稀释。

警告:
本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为,我们不承担任何责任。