产品名称:重组小鼠白介素17A(IL-17A)

产品英文名称:Mouse IL-17A Protein

货号:PRP1300

产品特点&优势:
通过LAL法测定,每微克蛋白里内毒素含量<0.1 EU。

重组小鼠白介素17A(IL-17A)产品背景:
Interleukin-17 (IL-17) is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

序列:
氨基酸序列来源于:小鼠源IL17A (Thr22-Ala158) (Q62386) 表达的蛋白片段。

标签:无标签

活性:
Testing in Progress

蛋白长度:
重组小鼠IL-17A由137个氨基酸组成,预测分子量为15.4KD

分子:
IL-17A

检测指标:
IL-17A

产品形式:冻干粉,冻干缓冲液为无菌的20 mM Tris,50 mM NaCl,pH 8.0。

重组小鼠白介素17A(IL-17A)产品注意事项:
开盖使用前,请先离心。本产品为冻干粉,推荐用该产品配套的Reconstitution Buffer进行复溶,且浓度不低于104 μg/mL。客户可根据后续的实验需求,进行进一步的稀释。

警告:
本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为,我们不承担任何责任。