产品名称:重组人R-脊椎蛋白1,His-SUMO标签(无动物源)(RSPO1/R-spondin 1)

产品英文名称:Human RSPO1/R-spondin 1 Protein, His-SUMO tag (Animal-Free)

货号:PRP1122

产品特点&优势:
通过LAL法测定,每微克蛋白里内毒素含量<1 EU。

重组人R-脊椎蛋白1,His-SUMO标签(无动物源)(RSPO1/R-spondin 1)产品背景:
R-spondin 1 (RSPO1, Roof plate-specific Spondin 1) is a cysteine-rich secreted glycoprotein that belongs to the R-Spondin family. Structurally, R-spondin 1 harbors an N-terminal signal peptide, two cysteine-rich furin-like (FU1-FU2) domains, a thrombospondin (TSP) domain, and a basic amino acid-rich (BR) C-terminal domain. R-spondin 1 acts as a ligand for the leucine-rich repeat-containing G-protein coupled receptor (LGR) family (LGR4/5/6), subsequent clearing negative regulators ZNRF3/RNF43 from the membrane, leading to the availability of Wnt receptor and activating Wnt/β-catenin signaling. The signal cascade is essential for regulating stem cell proliferation, embryonic development, and tissue homeostasis.

序列:
氨基酸序列来源于:人源RSPO1/R-spondin 1 (Ser21-Ala263) (Q2MKA7)

标签:His-SUMO

活性:
R-Spondin-1 enhances BMP-2-mediated differentiation of MC3T3-E1 cells. The ED?? for this effect is 1-3 μg/mL.

蛋白长度:
重组人RSPO1/R-spondin 1 蛋白由243个氨基酸组成,预测分子量为46.8 KD。

分子:
RSPO1/R-spondin 1

检测指标:
RSPO1/R-spondin 1

产品形式:液体,为无菌的PBS,pH 7.4。

重组人R-脊椎蛋白1,His-SUMO标签(无动物源)(RSPO1/R-spondin 1)产品注意事项:
开盖使用前,请先离心。本产品为冻干粉,推荐用该产品配套的Reconstitution Buffer进行复溶,且浓度不低于100 μg/mL。客户可根据后续的实验需求,进行进一步的稀释。

警告:
本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为,我们不承担任何责任。